Reverse transcriptase (RT) යනු RNA template එකකින් reverse transcription ක්රමවේදය හරහා (cDNA) නිපදවීමේදී භාවිතාවන එන්සයිමයක් වේ.
Reverse transcriptase (RNA-dependent DNA polymerase) | |||||||||
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![]() Crystallographic structure of HIV-1 reverse transcriptase where the two subunits p51 and p66 are colored and the active sites of polymerase and nuclease are highlighted. | |||||||||
Identifiers | |||||||||
Symbol | RVT_1 | ||||||||
PF00078 | |||||||||
clan | CL0027 | ||||||||
IPR000477 | |||||||||
PS50878 | |||||||||
1hmv | |||||||||
1hmv | |||||||||
cd00304 | |||||||||
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RNA-directed DNA polymerase | |||||||||
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Identifiers | |||||||||
2.7.7.49 | |||||||||
9068-38-6 | |||||||||
Databases | |||||||||
IntEnz view | |||||||||
BRENDA entry | |||||||||
NiceZyme view | |||||||||
KEGG entry | |||||||||
metabolic pathway | |||||||||
profile | |||||||||
structures | RCSB PDB PDBe PDBsum | ||||||||
AmiGO / QuickGO | |||||||||
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ඉතිහාසය
හි විසින් reverse transcriptases සොයාගත් අතර 1970 දී හි සිදුකරන ලද ස්වාදීන පර්යේෂණයක දී RNA tumour වෛරස දෙකක් වන සහ වලින් reverse transcriptase වෙන් කර ගන්නා ලදී. එම සොයාගැනීමට 1975 දී ඔවුන් දෙදෙනා හට ( සමඟ) හීමිවිය.
ආශ්රිත
මූලාශ්ර
- : 3KLF; Tu X, Das K, Han Q, Bauman JD, Clark AD, Hou X, Frenkel YV, Gaffney BL, Jones RA, Boyer PL, Hughes SH, Sarafianos SG, Arnold E (October 2010). "Structural basis of HIV-1 resistance to AZT by excision". Nature Structural & Molecular Biology. 17 (10): 1202–9. doi:10.1038/nsmb.1908. PMC 2987654. PMID 20852643.
- Temin HM, Mizutani S (June 1970). "RNA-dependent DNA polymerase in virions of Rous sarcoma virus". Nature. 226 (5252): 1211–3. doi:10.1038/2261211a0. PMID 4316301.
- Baltimore D (June 1970). "RNA-dependent DNA polymerase in virions of RNA tumour viruses". Nature. 226 (5252): 1209–11. doi:10.1038/2261209a0. PMID 4316300.
භාහිර සබැඳි
- RNA+Transcriptase at the US National Library of Medicine (MeSH)
- Molecule of the month 2020-04-09 at the Wayback Machine (September 2002) at the RCSB PDB
- HIV Replication 3D Medical Animation. (Nov 2008). Video by Boehringer Ingelheim.
- Goodsell DS. "Molecule of the Month: Reverse Transcriptase (Sep 2002)". Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (PDB). සම්ප්රවේශය 2013-01-13.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human immunodeficiency virus Reverse transcriptase